Long-term high blood pressure control is not good, the damage to the kidney is obvious. This will inevitably use all kinds of drugs to treat high blood pressure to control the increase in blood pressure, to avoid increased damage to the kidneys.
However, some patients with kidney disease have encountered such a situation: their blood pressure is not high, the doctor also asked to eat antihypertensive drugs. How is this going on?
Some antihypertensive drugs do not use what you think of "simple", there are many kinds of antihypertensive drugs, there are two kinds of very special, for patients with nephropathy, they not only have the function of blood pressure, and reduce proteinuria and protect renal function. These are antihypertensive drugs such as perindopril and losartan.
How can we reduce protein and protect renal function?
Drugs such as perindopril and losartan can dilate glomerular efferent arteries, relieve glomerular pressure, and reduce the permeability of glomerular capillaries to proteinuria, thus reducing the effect of proteinuria.
Urinary protein is an extremely important factor in the deterioration of renal function. The presence of persistent urinary proteins may continue to damage our renal function.
So for patients with hypertension with proteinuria, is medicine dual-use, but for one with proteinuria and normal blood pressure of the patients, can also be applied to such drugs.
Antihypertensive drugs need to pay attention to three major problems of protein lowering:
Avoid low blood pressure. In order to avoid long-term medication, leading to low blood pressure, kidney disease patients should pay attention to monitor their blood pressure, once there is a problem should be promptly reflected to their doctors.
The blood pressure in patients with nephropathy is below 130/80mmHg, but not less than 90/60mmHg. There are diarrhea, dehydration and so on, we should immediately disable these two categories, so as not to cause blood pressure is too low, causing insufficient renal blood flow.
Pay attention to the increase of serum creatinine. In general, elevated serum creatinine is acceptable in about 20% of the range. Elevated creatinine is usually temporary and increases significantly at the early stage, and serum creatinine slowly decreases over time.
Pay attention to the change of blood potassium. Most patients do not appear, and only a subset of patients, especially those with renal insufficiency, need attention.
In order to give full play to the efficacy of perindopril and losartan, one dose is the problem and the other is to control the salt! According to the conditions of patients using the dose should be formulated; high salt diet will increase against resistance, low salt diet helps to improve the effect of reducing protein, 3 grams of salt per day in patients with nephropathy (half a bottle of beer) would be okay. a maximum of not more than 6 grams.
Note: other types of antihypertensive without these two drugs to reduce the role of protein, do not blindly medication.
These two kinds of antihypertensive drugs can reduce urinary protein?