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What is urea nitrogen?

We generally know that serum creatinine is an indicator of renal function and usually ignores urea nitrogen. In fact, urea nitrogen and serum creatinine are two important indicators of renal function. It is the ultimate metabolite of protei...

What is urea nitrogen?

Jul 18, 2017 by Kidney Disease Expert

We generally know that serum creatinine is an indicator of renal function and usually ignores urea nitrogen.

In fact, urea nitrogen and serum creatinine are two important indicators of renal function.

It is the ultimate metabolite of protein in the human body and is excreted mainly through the glomerular filtration function. The value of urea nitrogen also reflects the quality of renal function.

The cause of high urea nitrogen

01 simple increase of urea nitrogen

Most of the simple increase in urea nitrogen is caused by the excessive intake of protein in the diet, which can quickly be restored by changing diet structure and balancing protein.

02 nephropathy elevated urea nitrogen

In addition to the simple increase of urea nitrogen, the increase of urea nitrogen in patients with kidney disease is mostly due to the impairment of renal function and oliguria, so that the urea nitrogen in the blood can not be excreted in the urine in time, resulting in accumulation in the blood.

How to judge it is simple or kidney disease reason?

We can use urea / creatinine ratio to distinguish whether urea nitrogen is renal or simple.

If urea nitrogen creatinine ratio is lower than 20, the probability of kidney disease is high, such as acute nephritis, chronic pyelonephritis, acute and chronic renal failure; if urea / creatinine ratio is higher than 20, the probability of simple (prerenal) is high, such as dehydration, heart failure, hunger, high protein diet, these are generally not associated with elevated serum creatinine.

But because the numerical value of urea nitrogen is easy to be influenced by other factors, it is also necessary to judge comprehensively.

In addition, if the urea nitrogen and creatinine did not rise, then the ratio of urea to nitrogen / creatinine would be meaningless.

High urea nitrogen hazard

Changes in urea nitrogen in renal patients are often associated with renal dysfunction.

In some patients with acute glomerulonephritis and nephrotic syndrome, there is a high degree of edema leading to a transient increase in urea nitrogen.

And because of nephritis, kidney damage, resulting in long-term accumulation of liquid in the body, urea nitrogen can not be discharged normally, thereby increasing high blood pressure, edema and other symptoms.

What is urea nitrogen?
What is urea nitrogen?

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