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Treatment of IgA nephritis

Recent data suggest that the use of adrenal corticosteroids for the next day of proteinuria is beneficial for the improvement of proteinuria. A small lesion with IgA deposits may alleviate proteinuria. The combined use of cyclophosphamide,...

Treatment of IgA nephritis

May 08, 2017 by Kidney Disease Expert

Recent data suggest that the use of adrenal corticosteroids for the next day of proteinuria is beneficial for the improvement of proteinuria. A small lesion with IgA deposits may alleviate proteinuria. The combined use of cyclophosphamide, pantinine and huafin could reduce the effect of the glomerular filtration rate without affecting the glomerular filtration rate. The combination of cyclosporin A also reduces proteinuria and reduces the rate of creatinine clearance. The curative effect of phenytoin sodium, antiplatelet agent, disodium chromate, diphenyl hydrochloride, etc. Is not certain. Although there are reports of the role of ureterases in the protection of glomerular filtration rates, it is far from conclusive.

So far, there is no satisfactory treatment for the disease. The results of the use of corticosteroid partners, or non-immune inhibitors, were not consistent with this disease.

Repeated episodes of tonsillitis, which may be beneficial; Antibiotic prevention and treatment infection may be helpful for some patients with acute nephrotic syndrome and acute kidney failure. A smaller series of observations found the use of fish oil preparation for reducing albuminuria and increasing glomerular filtration rate. Serious IgA nephropathy (glomerular filtration rate monthly fall in 2 ~ 4 ml/min) using high-dose immunoglobulin during intravenous drip, can stop the glomerular filtration rate decreased, improve hematuria and proteinuria, but often relapse after drug withdrawal.

When IgA nephropathy was received by the end-stage IgA nephropathy, the transplanted kidney was soon followed by IgA deposit in the membrane area. If the donor has subclinical IgA nephropathy, the IgA deposit in the renal membrane area is frequently rapidly disappearing after the implant is implanted in the non-iga nephrotic disease. Does not necessarily occur graft with recurrent IgA nephropathy progressive renal failure, however after kidney transplantation immunosuppressive therapy, including ring spore A also does not stop its development.

For body renal transplantation, 1 year and 3 year graft survival rate can reach 87% and 77%, but the inpidual has the HLA antigen IgA antibodies, IgA kidney transplants with 2 year graft survival rate can reach 100%, there is reason to believe that these anti HLA antigen antibody to increase graft survival rate plays a useful role.

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