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Whether IgA has genetic?

Many IGA patients will be questioned that iga nephropathy is genetic, in fact, iga kidney disease is not genetic. Kidney disease is mainly due to iga immunoglobulin abnormal deposition of glomerular mesangial area, which led to kidney disea...

Whether IgA has genetic?

Aug 14, 2017 by Kidney Disease Expert

Many IGA patients will be questioned that iga nephropathy is genetic, in fact, iga kidney disease is not genetic. Kidney disease is mainly due to iga immunoglobulin abnormal deposition of glomerular mesangial area, which led to kidney disease. It is a kind of immune system defective disease, many incentives, usually repeated inflammation, tonsillitis, cold and other causes. Iga nephropathy will only cause damage to the kidneys inherent cells, there will be no iga kidney disease genetic phenomenon.

Optical microscopy confirmed IgA nephropathy is the most common change is that mesangial cell matrix regional focal or diffuse dilatation, peculiar glomerular mesangial cells and matrix expansion is IgA nephropathy in many other kidney diseases are also observed the change of the glomerular diseases including diabetic nephropathy. Damage associated with focal segmental glomerulosclerosis and many mesangial diseases.In addition, a variety of lesions identified by optical microscopy can be seen in iga nephropathy, including diffuse capillary endothelial proliferation, segmental sclerosis, segmental necrosis and cell crescent formation.

Light microscopic lesions mainly involved in glomerular lesions, a variety of types, including mild lesions, mesangial proliferative lesions, focal segmental lesions, endocapillary proliferative lesions, crescentic lesions and sclerosing lesions, most of the patients with diffuse mesangial proliferation is a typical change, including the proliferation of mesangial cell and system the membrane matrix increased. According to the severity of the lesion, it can be further pided into mild, moderate and severe mesangial proliferative glomerulopathy. Eosinophilic deposits were found in the mesangial region by Masson staining, usually distributed in the region of the mesangial region. The lesion was mild, only slight mesangial hyperplasia and diffuse proliferation.

The above is the relevant introduction about whether IGA has genetic, although IGA nephropathy is not hereditary, but the patients to do nursing but also in daily life, if you have a kidney disease knowledge requires a detailed understanding, you can consult our online expert, our experts will reply as soon as possible

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