Iga nephropathy is clinical understanding of nearly 40 years, with the deepening of the study, changed the cognition of IgA nephropathy, especially the research progress in genetics, will no longer be IgA nephropathy as an independent disease entity to treat, clinical disease type, disease or physical disease progression rate perplexing the result is, by genetic factors.
In pathological analysis, IgA nephropathy is mainly IgA antibody or immune complex deposition in the glomerular mesangial area, leading to mesangial cell damage, resulting in a series of inflammatory response. Large numbers of mesangial cells proliferate or contract, resulting in microcirculatory disturbance, leading to ischemia and hypoxia. Due to ischemia and hypoxia resulting in a large number of renal capillary endothelial cells, epithelial cells, renal interstitial fibroblast damage and transdifferentiation of renal fibrosis formation; endothelial cells or epithelial cells damaged by the basement membrane and charge barrier function changes, resulting in a large number of protein and red blood cell leakage, the formation of proteinuria and hematuria.
According to the above discussion, the leakage of proteinuria and red blood cells in kidney disease is mainly due to the increase of permeability caused by the damage of glomerular filtration membrane. At present, if antibody and immunoglobulin is the application of hormone, Tripterygium wilfordii, cyclophosphamide inhibition based on IgA production, it is the treatment for primary disease; can not remove the deposited IgA receptor and immune complexes, hypoxia ischemia in the kidney does not improve, treatment can not be completely eliminated by mesangial and a series of reactions caused by damaged cells, but can not effectively repair the glomerular filtration membrane, restoring the normal filtration function. Therefore, the application of hormone, cyclophosphamide or just because of a triptolide suppressed various receptors, a control inflammatory reaction and damage progress, the urine protein and occult blood to reduce or even disappear in a period of time. But the most fundamental cause is not resolved, in the role of the drug disappeared, or for some reason by the induction of urine protein and occult blood will relapse.
The reason of IgA nephropathy is repeated Yu introduced to this, I hope you can help, if you need to have a detailed understanding, you can consult our online expert, our experts will reply as soon as possible.