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The largest harm of IgA nephropathy— uremia

Lots of patients with IgA nephropathy in the early detection did not fully realize the seriousness of the IgA nephropathy, they aim at symptoms, proteinuria, hematuria, they did not have systemic therapy for the primary disease of kidney di...

The largest harm of IgA nephropathy— uremia

Jun 11, 2014 by Kidney Disease Expert

Lots of patients with IgA nephropathy in the early detection did not fully realize the seriousness of the IgA nephropathy, they aim at symptoms, proteinuria, hematuria, they did not have systemic therapy for "the primary disease of kidney disease , but IGA nephropathy repeat, it can cause" pathological "renal injury, it finally develop into kidney failure uremia, renal fibrosis is irreversible, it can endanger patients’ life in the end.

The biggest harm of IgA nephropathy is to induce uremic

Relevant data shows, people used to think that IgA nephropathy is a kind of disease for good prognosis, IgA nephropathy is a progressive disease, only 5% - 30% of the patients with IgA nephropathy can ease completely abnormal urine test, most patients are chronic progressive development.Since starting symptoms, every 10 years about 20% of patients develop into end-stage renal disease, renal failure, uremia.

IGA nephropathy and other types of kidney disease develop into renal failure and uremia, the average person will say the disease isn’t controlled to cause deterioration.The real reason is renal fibrosis.IgA nephropathy or other kidney disease develop into renal failure and uremia, which is the essence of renal fibrosis leading to effective renal units and renal function progressively declining. Accurately, The forming process of renal failure and uremia is the process of renal fibrosis.

With the continuous development of renal fibrosis, loss of function of hardening cells gradually increase, the health of the nephron is less and less.When healthy renal units is less than 20%, it enter the stage of renal failure.Acidosis and some symptoms of uremia start to appear.Some experts call renal fibrosis matrix synthesis stage.When 90% of the cells in the kidney appear fibrosis, patients would appear serious metabolic acidosis, a series of worsening symptoms of heart and brain, it also enter the period of uremia at this time.

Uremia is the ultimate sign of IgA nephropathy renal fibrosis expansion, blocking the deterioration of development of IgA nephropathy developing into renal failure and uremia must start from blocking the process of renal fibrosis.

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