With lupus nephritis refers to the different pathological types of systemic lupus erythematosus (sle) with double kidney immune damage, at the same time companion has apparent kidney damage of clinical manifestations of a disease. Lupus nephritis is a disease of the immune complex that occurs in the human body against the endogenous antigen, which is often accompanied by T cell dysfunction. Therefore, how to eliminate abnormal immune complex quickly is the key to treating lupus nephritis.
On treatment with lupus nephritis, the conventional method is the application of glucocorticoid (a hormone steroid) or (and) cyclophosphamide, mycophenolate mofetil, such as immune inhibitors, the drugs mainly by lymphocyte proliferation, inhibition of autoantibody production and anti-inflammatory effects make remission. However, most drugs used in conventional treatment have a strong side effect, with poor prognosis and high recurrence rates.
Immuno-adsorption therapy is a new type of blood purification therapy developed in recent years and is a highly selective new technique for immunotherapy. It is through the extracorporeal circulation to antigens, antibodies or certain affinity with a particular physical and chemical substances as ligands with carrier, made IA column, using its specific adsorption performance, selectivity and specificity to eliminate pathogenic substances in the blood, to cleanse the blood, alleviate the purpose.
With lupus nephritis treatment is the key to clear a lot of their sexual antibody in the blood plasma, to rapidly control lupus activity, give patients clinical relief, however, patients often accompanied by hypoalbuminemia, infection, edema, heart function not congruent symptoms, this makes it hard for patients treated with large doses of the hormone and immune inhibitor, cause may increase again and again. This situation has improved considerably since the introduction of immunosorption therapy.
In the treatment of lupus nephritis, immunosorption can improve the immune condition of the body by removing large molecules from the blood circulation. From the perspective of humoral immunity, to clear its own antibodies or pathogenic, circulating immune complex and inflammatory factor, to clear the influencing factors of coagulation and blood flow dynamics; From the perspective of cellular immunity, can correct the ratio of CD4 / CD8 cells, patients with the ratio of CD25 cells, reduce their activation of T cells, so as to achieve therapeutic effect.
Not only that, the immune adsorption while patients with plasma exchange as cleared by disease-causing agents in the body and relieve the illness, but the immune adsorption with high selectivity and specificity, the impact on the normal plasma ingredients such as clotting factors mild, little influence on drug concentration in the body as well. In the process of immune adsorption treatment, the patients of autologous blood plasma was back to lose, don't have to exogenous plasma infusion, put an end to the transfusion reaction and the possibility of various blood-borne infectious diseases occur. The patient also does not need to replenish the balance fluid, the effect of water, electrolyte and acid base balance in the body is very slight.
A large number of clinical practice has proved that application of immunoadsorption therapy with lupus nephritis, the majority of patients are overcast or significantly reduce albuminuria, compared with the conventional treatment for patients with renal function recovery sooner, the better, can achieve good prognosis.