What is creatinine? In our lives, we must have a certain understanding of creatinine , also we should know what is the reason of low creatinine, let us come together to understand what the reasons for low creatinine.
Low creatinine causes
Creatinine is the product of muscle metabolism in the body, every 20g muscle metabolism can produce 1mg creatinine. Creatinine is mainly drained by glomerular filtration. Blood creatinine from both exogenous and endogenous, exogenous creatinine is the product of meat in vivo metabolism; endogenous creatinine is the product of muscle tissue metabolism in vivo. In the meat food intake is stable when the body's muscle metabolism and no major changes in the generation of creatinine will be relatively constant. So what is the main reason for low creatinine? Let us have a detailed look.
As the kidneys are invaded by various causes, the first damaged cells in the kidneys are phenotypic transformation, stimulating the transformation of fibroblasts into myofibroblasts, and simultaneously invading and stimulating the inherent normal renal tissue. Of the disease, which formed the kidney from point to surface, from the local to the whole, to expand the excitement of the spread of the process, which entered the equipment damage period (ie, renal injury), this time due to kidney damage caused by its excretion waste function has been reduced, resulting in creatinine and other toxins gathered in the body, resulting in blood creatinine, elevated urea nitrogen, urinary creatinine decreased, renal filtration rate decreased.
Low creatinine has a variety of reasons, low creatinine may be associated with anemia, creatinine malnutrition, muscle atrophy, leukemia, diabetes insipidus and other diseases. In the creatinine value of a test data value is called urea nitrogen value, the urea nitrogen value is very susceptible to many other factors, it can not simply react to kidney function.
Creatinine values in the absence of muscle disorders, which are relatively simple, can be synchronized with renal function. So when the kidney itself is sick, urea nitrogen, creatinine increased simultaneously, so the urea nitrogen / creatinine ratio will drop to a certain range (less than 20).
The above is the causes of the low creatinine, if you want to learn more about creatinine, please contact our online doctor.