Abdominal obesity is adipose tissue accumulation in abdominal cavity and abdominal organs inside and outside, most patients have abdominal obesity, studies have shown that there is diabetic patients with abdominal obesity susceptibility to diabetic nephropathy, the reason for abdominal obesity can lead to the body has the following three kinds of abnormal changes, promote the occurrence of diabetic nephropathy.
One. Abnormal secretion of adipocyte cytokines in abdominal obesity leads to kidney injury
Intraperitoneal adipose tissue is not only a special fatty tissue, adipose tissue but has endocrine function active, they secrete a series of adipocytokines, such as leptin, resistin and adiponectin. These factors in energy homeostasis and regulating the upheaval of God by endocrine system, reproductive system, autonomic nervous system and immune system function have an important role in the abnormal secretion of abdominal obesity in patients with diabetes these factors can lead to kidney damage correlation, promote the occurrence of diabetic nephropathy.
Two, abdominal obesity may lead to insulin resistance
Obesity is a major cause of insulin resistance. Insulin resistance refers to the decline in the efficiency of insulin to promote glucose uptake and utilization due to various reasons, and the body's compensatory secretion of excessive insulin produces hyperinsulinemia to maintain blood glucose homeostasis. In diabetic patients, insulin secretion decreases due to pancreatic injury. If insulin resistance occurs, blood glucose control is more difficult and complications occur more quickly, including diabetic nephropathy.
Three. Abdominal obesity can activate inflammatory response
Inflammatory factors in abdominal obesity have increased in varying degrees. It is generally believed that inflammatory response plays an important role in the increase of extracellular matrix and irreversible process of renal fibrosis. Inflammatory reactions may not directly result in renal interstitial fibrosis, but accelerate the process, which is the cause of diabetic nephropathy.
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