Recently, the American Association of Kidney Diseases (JASN) published an online epidemiological survey of renal pathologic changes and air pollution in the National Academy of Southern Medicine Hospital of Southern Medical University, China, which covers 282 cities in China , 938 hospitals, the total number of up to 71151 people, the time span from 2004 to 2014.
The study retrospectively analyzed the changes in glomerular disease patterns over the past 11 years. IgA nephropathy remains the most common pathological type (28.1%) for renal biopsy and glomerular disease, and the second has become membranous Kidney disease (23.4%), after statistical correction found that membranous nephropathy in the past 11 years is 13% annual rate of growth, faster, has more than IgA nephropathy trend.
As we all know, Hebei Province is currently one of the most polluted provinces in China, so the researchers put forward the assumption that long-term air pollution exposure, and the increase in membranous nephropathy have a certain relationship, followed by researchers published in recent years through the national 3-year average PM2.5 distribution, and nearly three years of national air quality index and other air pollution indicators found: in the correction of age, sex, geographical and clinical factors, more PM2.5 exposure and the occurrence of membrane Kidney disease risk, and this relationship is non-linear, PM2.5> 70 ug / m3 in the region, PM2.5 each increase of 10 ug / m3, the risk of membranous nephropathy will increase by 14%.
This study provides evidence of long-term air pollution (PM2.5) exposure and increased risk of membranous nephropathy, and researchers point out that this is only the beginning of our understanding of the relationship between air pollution and membranous nephropathy. More animal experiments and prospective studies are needed to explore this area in depth. Away from the kidney disease, the future from the protection of the environment began!