How does proteinuria appear? There are many types of kidney disease, proteinuria is one of them, What is the reason that kidney disease patients with proteinuria ?
The formation of nephrotic Syndrome is a large number of proteinuria due to a variety of pathological factors caused by the barrier function of the membrane is destroyed, such as large pore size or negative charge reduction, resulting in a large number of protein leakage, and far more than the weight of tubules Absorption capacity, so there is a lot of proteinuria.
Water in the blood in and its solute through the glomerular filtration into the renal capsule to form the original urine, must pass through the capillary wall of the endothelial cells, basement membrane and epithelial cells, the three-layer structure called glomerular filtration membrane. The three-layer membrane has a certain pore, only allow a certain molecular weight and molecular diameter of the material through, thus forming the membrane membrane pore barrier, and three-layer structure of the surface were covered with sialyl protein, glomerular basement membrane , The outer loose layer is rich in heparin sulfate, these substances in the human body fluid environment with a negative charge, the exclusion of negatively charged solute through, thus forming the filter membrane charge barrier.
The glomerular mesentery is located between the glomerular capillaries for the regulation of the glomerular filtration barrier, and thus the glomerular filtration also play a certain role. Under normal circumstances, the vast majority of the blood. Proteins can not pass through the glomerular filtration barrier, especially macromolecules and negatively charged albumin is almost completely through, a small amount of small molecules through the membrane protein can be reabsorbed in the renal tubules.
Although about 10 to 15 kg of plasma protein flows through the kidney every day. But the protein discharged from the urine less than 150mg. In the nephrotic syndrome, due to various pathological factors, the barrier effect of the membrane is destroyed, such as pore size or negative charge reduction, resulting in a large number of protein leakage, and far more than the renal tubular reabsorption capacity, So there is a lot of proteinuria.
The above is about how does proteinuria appear, if you have proteinuria, please go to the hospital to check to determine the reasons for the emergence of proteinuria.