Lupus nephritis is a renal damage caused by systemic lupus erythematosus, as well as one of the more common kidney disease in daily life, but also for our kidney caused by one of the serious injury disease, so we draw a serious health alarm. So what is the cause of the incidence of lupus nephritis? The following tongshantang experts will introduce 5 of the most common causes of lupus nephritis.
First, we all most helpless of a genetic factor, the survey data show that genetic factors in the lupus nephritis disease play a decisive role in the disease. Patients with lupus nephritis generally have family history, the prevalence rate of close relatives is very high. HLADR2 detection rate was significantly higher than that of normal inpiduals. HLADQW1, HLADQW2, HLAB8, also see more. In addition, C2, C4, Clr, and Cls are less susceptible to lupus nephritis. The development of molecular biology theories and techniques has deepened the immune inheritance of lupus nephritis. Second, psychological factors, which is what we are in these factors the most easy to control, and the most easy to avoid exercise. Psychological stress to promote the onset of lupus nephritis, but also can cause lupus nephritis; however, should be the inpidual response to the inpidual strength of the hand. Personality traits and stress events, duration, and frequency of events. Third, the impact of sex hormones, which is why lupus nephritis occurs in the root causes of women, women in the highest incidence of growth, so that estrogen and the disease occurred. Pregnancy can worsen half of the patients. Lupus nephritis experimental animals to estrogen to make the disease worse, such as to give androgen can relieve the disease. Has been found in patients with this disease, both men and women, their estrone hydroxylation products are increased, while testosterone is reduced. Fourth, ultraviolet radiation, skin cells by UV stimulation, secretion of interleukin. One is to stimulate the B cells, and induce T cells to produce interleukin, the second is to stimulate the immune system to worsen the disease. Some people think that ultraviolet light to DNA into thymine dimer, the antigen increased. Daylight allergy found in 40% of patients with lupus nephritis. Cold or strong electric light can also induce or aggravate the disease. The five is a viral infection, detection of C virus RNA in patients with lupus nephritis mice NZB/NAWF1 New Zealand hybrid organization, although not yet to prove the existence of the tissue of the patient virus, but serum DNA antibody can be detected in RNA.
This can be seen there are many reasons can cause lupus nephritis, which also increased the difficulty of treatment of lupus nephritis, but the patients with lupus nephritis do not have to worry too much and fear, regardless of any disease, can be found in the treatment.