Many data show lupus nephritis appear more middle age women and young women, many patients have proteinuria, red and white cells in the urine, tube type urine and nephrotic nephropathy, they can accompany with edema, high blood pressure or reducing renal function, it is common to increase enuresis nocturna. Fewer patients have sudden onset, renal function deteriorate quickly. Kidney most occurs involvement in renal outward manifestation such as fever,arthritis,skin rashes. The serious patients can be involved in serous, heart, lungs, liver,hematopoietic organ tissue and other organs, it can accompany with clinical performance. About one forth of patients have the first performance of renal damage.
The fever is common in the acute period, most patients have anemia, facial butterfly erythema. Patients can accompany with joint swelling, hair loss, skin rashes or pericardial effusion, heart murmur, hepatosplenomegaly, swollen lymph nodes, and different degree of swelling or chest water, etc.
Urine tract examination have different degree urine protein,microscopic hematuria, white blood cells, red blood cells and urine tube type.
Most patients have middle anemia, it has hemolytic anemia, decreasing blood leukocytes and platelets most less than 100 x 109 / L, blood sedimentation quickly.
The immunological tests: A variety of serum autoantibodies are positive, gamma globulin increase significantly,circulating immune complex is positive, complement hematic disease is low especially in the activity. Blood lupus erythematosus (sle) cells are positive, the skin lupus band test is positive.
Heavy activity associated with lupus nephritis can accompany with reversibility of Ccr declining in different level, blood urea nitrogen and creatinine increase,hepatic transaminase heighten blood albumin reduce;End-stage Ccr decrease obviously with lupus nephritis and serum creatinine, blood urea nitrogen increase obviously.
Imaging examination: Ultrasound in bilateral renal enlargement show acute lesions;Some patients can accompany with liver and spleen enlargement or pericarditis.
Renal biopsy can understand pathologic type, disease activity and determining treatment. Renal biopsy is helpful to diagnosis for kidney damage as the starting performance of systemic lupus erythematosus.