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Treatment of uveitis syndrome with tubulointerstitial nephritis

Tubulointerstitial nephritis uveitis syndrome common in women, children and adolescents more common, but also seen in adults, all ages can be disease. Patients with non - specific prodrome before onset , such as hypodynamia , anorexia , nau...

Treatment of uveitis syndrome with tubulointerstitial nephritis

Jan 02, 2018 by Kidney Disease Expert

Tubulointerstitial nephritis uveitis syndrome common in women, children and adolescents more common, but also seen in adults, all ages can be disease. Patients with non - specific prodrome before onset , such as hypodynamia , anorexia , nausea , weight loss , etc. This disease is extremely harmful to the patient, so treatment becomes even more important. This article mainly introduces the treatment of tubulointerstitial nephritis uveitis syndrome.

Treatment of uveitis syndrome with tubulointerstitial nephritis

Treatment of tubulointerstitial nephritis uveitis syndrome:

The treatment of tubulointerstitial nephritis is mainly systemic glucocorticoid, prednisone commonly used preparation, oral dose is generally 1m / (kg · d), the treatment time of 3 weeks to 12 months, the treatment time should not be too short, should be in 5 to 12 months is appropriate, rapid reduction of the drug can easily lead to elevated serum creatinine.

The treatment of uveitis mainly uses glucocorticoids and cycloplegic eye drops. For bilateral acute and severe anterior uveitis, eye drops should be given dexamethasone eye drops, once per hour, after the inflammation control according to the situation gradually reduce the eye frequency. Such as eye drops eye drops caused by treatment of intraocular pressure can be increased, adjust the frequency of eye drops or the use of glucocorticoids with little side effects, such as flumethasone prednisolone, rimexolone, etc., and give anti-glaucoma medication eye treatment. Cycloplegic usually use 2% horsetail ophthalmic cream, 1 times / d, later with the inflammation alleviated, and gradually reduce the frequency of eyelid. Can also be used non-steroidal anti-inflammatory eye drops eye treatment.

If the treatment is not satisfactory, consider giving oral glucocorticoid therapy, the general dose of 30 ~ 40mg / d (prednisone), morning meal service, about 1 week after the reduction, the treatment time should not be too long, the treatment should pay attention to the side effects of this medicine. If patients are not sensitive to glucocorticoids (mostly in patients with posterior uveitis), consider the use of other immunosuppressive drugs, such as chlorambucil 0.05 ~ 0.1mg / (kg · d), methotrexate (7.5 ~ 15mg / week), cyclosporine 3 ~ 5mg (kg · d), azathioprine 1 ~ 2mg (kg · d), these drugs can be used alone or in combination. However, in the course of treatment should be regular liver and kidney function and (or) blood and other aspects of inspection, so as not to cause serious side effects.

Syndrome differentiation of traditional Chinese medicine for reducing renal damage, promote the recovery of renal function and uveitis, and reduce the toxic and side effects of immunosuppressive agents.

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