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Why does glomerulonephritis lead to high blood pressure?

Unfortunately, some friends got kidney disease or nephritis, and they should pay attention at this time; because it may be associated with hypertension, and the incidence rate is very high, about 70%-80%, and high in both systolic blood pre...

Why does glomerulonephritis lead to high blood pressure?

Jul 06, 2017 by Kidney Disease Expert

Unfortunately, some friends got kidney disease or nephritis, and they should pay attention at this time; because it may be associated with hypertension, and the incidence rate is very high,  about 70%-80%, and high in both systolic blood pressure and diastolic blood pressure; in clinical it is a kind of serious complication. The main reasons are as follows:

Water and sodium retention: the fundamental pathological changes in patients with acute glomerulonephritis are sodium and water retention. The retention of sodium and water due to various causes leads to an increase in blood volume, resulting in "blood volume dependent hypertension".

Renin secretion in patients with acute glomerulonephritis: renin secretion, this is because renal ischemia stimulates renin angiotensin secretion, small artery spasm, peripheral blood flow resistance increased, causing "renin dependent hypertension".

Injury of the renal parenchyma: acute glomerulonephritis can cause renal parenchymal damage, decrease the secretion of depressor substances in the kidney, and reduce the production of kallikrein and prostaglandin by the kidney. This is also one of the causes of increased blood pressure.

The cause of hypertension associated with glomerulonephritis is relatively clear, mostly due to renal lesions, resulting in blood volume status and kidney lesions, which may contribute to the increased secretion of kidney boosting substances.

High blood pressure can accelerate kidney function deterioration. Therefore, hypotension is regarded as an important aspect in the treatment of acute glomerulonephritis. For hypertension caused by acute glomerulonephritis, under normal circumstances, after getting effective diuresis, blood volume can be returned to normal, blood pressure will gradually recover, and when necessary, antihypertensive drugs can be added.

 

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