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Causes of high edema in nephrotic syndrome

1. the decrease of plasma colloid osmotic pressure: the exchange of internal and external fluid is regulated by the osmotic pressure of both sides. Osmotic pressure including crystal osmotic pressure and colloid osmotic pressure, the former...

Causes of high edema in nephrotic syndrome

Jan 15, 2018 by Kidney Disease Expert

1. the decrease of plasma colloid osmotic pressure: the exchange of internal and external fluid is regulated by the osmotic pressure of both sides. Osmotic pressure including crystal osmotic pressure and colloid osmotic pressure, the former from crystal material (mainly because of its free electrolyte), through the capillary wall, so it has little effect on vascular and fluid exchange; the latter mainly from protein, because it can not freely through the capillary wall, which is a major factor in the blood vessels of the exchange of body fluids. Nephrotic syndrome, due to the large number of protein loss in the urine, caused by hypoproteinemia, resulting in plasma colloid osmotic pressure decreased, when the normal 3.3 ~ 4kPa to 0.8 ~ 1.1kPa, to the high permeability of the interstitial fluid movement of intravascular water, and edema.

2. effective blood volume reduction: plasma water moves the effective blood volume reduction, which led to the following changes in vivo: by volumereceptor the antidiuretic hormone (ADH) increased, the renal tubular reabsorption of water increased; by the activation of renin angiotensin aldosterone system, produce secondary aldosteronism. The renal tubular sodium reabsorption; inhibition of natriuretic factor production to reduce renal sodium excretion. In this way, retention of water and sodium in the body further aggravates the edema.

The above two factors cause nephrotic syndrome edema, hoping to help you, appear swollen symptoms, must be timely to the hospital for examination, so as not to delay the best time for treatment, if you need to have a detailed understanding, can consult our online expert.

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