According to the different pathological，nephrotic syndrome is pided into primary nephrotic syndrome, congenital nephrotic syndrome and secondary nephrotic syndrome. There are four characteristic of the clinical manifestation of nephrotic syndrome patients Nephrotic syndrome patients clinical manifestation has four characteristics: a large amount of proteinuria, edema, hypoalbuminemia and hyperlipidemia. Now, I would like to give you some specific introduction of clinical manifestations of nephritic syndrome.
1 massive proteinuria
The most component of proteinuria is albumin, and also contains other plasma protein. The proteinuria of patients more than 3.5 grams per day, it may be have urinary lipid. When the Glomerular filtration rate falls, the proteinuria will decrease; when the Severe hypoalbuminemia occurs, the urine protein excretion quantity can increase, high-protein diet can increase the excretion of urine protein.
The most notable symptoms of patients is that the gradually increasing anasarca. In the morning, the eyelid, facial and ankle will occurs edema. With the progression of disease, the edema can be spread to the whole body, and pleural effusion, ascites, pericardial effusion, mediastinal effusion, scrotal edema or labia, also can appear pulmonary edema.
Hypoalbuminemia refers to the serum albumin below 30grams per liter, when the liver albumin is not enough to compensate for the loss of urine protein, it will occurs hypoalbuminemia.
The hyperlipidemia is associated with hypoalbuminemia, this may occurs lipid urine, and there will appears the double refraction fat body, for it contains cholesterol or fat body tube type of epithelial cells.