People with kidney disease are getting more and more young. When you have kidney disease, the common symptom is proteinuria. Why does this happen? Is proteinuria serious for nephrotic syndrome?
1, long-term hypoproteinemia may lead to malnutrition, growth in children will develop stunting.
2. Reduction of immunoglobulin can cause the patient's immune system to be low, which can easily lead to infection.
3, the loss of metal binding protein will cause the lack of trace elements (iron, copper, zinc, etc.).
4, lack of endocrine binding protein can induce endocrine disorders.
We know that many patients with nephrotic syndrome will have a lot of proteinuria, and the reason is that many patients and their families want to know. The water in the blood and its solute are filtered through the glomerulus into the renal capsule to form the original urine, which must pass through the endothelial cells, basement membrane and epithelial cells of the capillary wall. This three-layer structure is called glomerular filtration membrane.
The three-layer filtration membranes have certain pores, and can only allow the passage of certain molecular weight and molecular diameter substances, thus constituting the pore size barrier of the filtration membrane, and the three-layer structure surface is covered with sialoprotein and glomerular basement membrane. The outer loose layer is rich in heparan sulfate. These substances have a negative charge in the human body fluid environment and repel negatively charged solutes, thus constituting a charge barrier of the filter membrane. In addition, the mesangium located between the glomerular capillaries has a regulatory effect on the glomerular filtration barrier, thus exerting a certain influence on the glomerular filtration fluid.
Under normal circumstances, the vast majority of blood. Proteins cannot pass through the glomerular filtration barrier. Especially, macromolecules and negatively charged albumins can hardly pass through. Small amounts of small proteins that pass through the filter membrane can be reabsorbed in the renal tubules. Therefore, although about 10~15kg of plasma protein flow through the renal circulation every day. However, less than 150 mg of protein is excreted from the urine. In nephrotic syndrome, due to a variety of pathological factors, the barrier function of the filter membrane is destroyed, such as larger pore size or reduced negative charge, resulting in a large number of protein leakage, and far exceeds the renal tubular reabsorption capacity, Therefore, a large amount of proteinuria occurs.
For patients with nephrotic syndrome, after a large number of proteinuria must not panic, and actively cooperate with the doctor's treatment, so as to get health as soon as possible.