Long-term use of hormones can cause atrophy or insufficiency of the adrenal cortex, inducing and aggravating ulcers or even neuropsychiatric symptoms, causing great obstacles for the rehabilitation of patients.
1, long-term super-physiological dosage of glucocorticoid can cause water, salt, sugar, protein and fat metabolism disorders, adrenal hypercortisias. Performance of centripetal obesity, resulting in calcium absorption disorders, osteoporosis, severe cases can occur spontaneous fractures.
2, glucocorticoids can weaken the body's ability to defend the disease, is conducive to bacterial growth and reproduction, proliferation or induce or aggravate the infection.
3, glucocorticoids promote protein breakdown, can delay the formation of granulation tissue, prevent trauma or surgical wounds and other ulcer healing.
4, glucocorticoids have the role of growth hormone, long-term use of children can inhibit bone growth and protein synthesis, affecting growth and development, pregnant women can also cause fetal malformations.
5, long-term use of glucocorticoid treatment, after the basic control of symptoms, such as reduction too fast or sudden withdrawal, the original symptoms may appear or aggravated rapidly, known as the "rebound phenomenon." There are some symptoms of the original disease, such as muscle pain, muscle rigidity, joint pain, etc., said withdrawal symptoms
The treatment of hormones does not solve the real problem, therefore, for the application of hormones must be modest, not blindly pursue the effect of a large number of hormone use, patients should not just stare at laboratory indicators, into the wrong direction in the treatment.
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