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The risk of nephrotic syndrome can not be underestimated

People for kidney disease, mostly just stay in the kidney stones, kidney deficiency, nephritis and other diseases above, you know? There are many kinds of kidney disease, such as renal insufficiency, pyelonephritis and so on, different symp...

The risk of nephrotic syndrome can not be underestimated

Jun 09, 2017 by Kidney Disease Expert

People for kidney disease, mostly just stay in the kidney stones, kidney deficiency, nephritis and other diseases above, you know? There are many kinds of kidney disease, such as renal insufficiency, pyelonephritis and so on, different symptoms of kidney disease is not the same, the treatment method Will be different, the following we come to see what causes the cause of kidney disease in the end what.

Infection: due to a large number of immunoglobulin loss from the urine, plasma protein decreased, affecting antibody formation. Adrenal cortex hormones and cytotoxic drugs, so that patients with systemic resistance decreased, prone to infection, such as skin infections, primary peritonitis, respiratory infections, urinary tract infections, and even induced sepsis.

Coronary heart disease: nephrotic syndrome patients often hyperlipidemia and hypercoagulable state of blood, so prone to coronary heart disease. It has been reported that the incidence of myocardial infarction in patients with nephrotic syndrome is 8 times higher than that of normal people. Coronary heart disease has become the third factor in the cause of death of nephrotic syndrome (second only to infection and renal failure).

Thrombosis: Nephrotic syndrome patients prone to thrombosis, especially the incidence of membranous nephropathy up to 25% to 40%. The formation of thrombosis causes edema, the patient activity less, venous stasis, high blood lipids, blood concentration to increase the viscosity, fibrinogen content is too high and v, Ⅶ, Ⅷ, x factor increased and the use of adrenal cortex hormones and blood prone High coagulation state and so on.

Acute renal failure: nephrotic syndrome patients due to a large number of proteinuria, hypoproteinemia, hyperlipidemia, the body often in the low blood volume and hypercoagulable state ¨ vomiting, diarrhea, the use of antihypertensive drugs and diuretics large diuretic , Can make a sudden reduction in renal blood perfusion, and thus reduce the glomerular filtration rate, leading to acute renal failure. In addition, nephrotic syndrome, renal interstitial edema, protein formation of tubular obstruction of renal tubular and other factors, can also induce acute renal failure.

Electrolyte and metabolic disorders: repeated use of diuretics or long-term unreasonable to ban salt, can make nephrotic syndrome patients with secondary hyponatremia; the use of adrenal cortex hormones and a large number of diuretics lead to a large number of urination, if not timely potassium, easy Hypokalemia occurs.

General therapy

Resting severe edema and high blood pressure when bed rest, generally without strict restrictions on activities.

Diet with high blood pressure and edema, given salt and low salt diet, not long-term ban salt. Severe edema when the control into the amount. Large doses of hormone during the application should be appropriate to add vitamin D and calcium.

Prevention and treatment of infection attention to skin care, to avoid public places to prevent cross-infection, generally do not advocate preventive antibiotics, in the event of infection is positive and timely treatment.

Diuretics application of hormone-sensitive cases of medication 7 to 10 days after the diuretic can occur, so no diuretics, but the edema of the chest, ascites and breathing difficulties, or because the infection can not take hormones, you can give Diuretics to improve the body condition. General use of hydrochlorothiazide, spironolactone or albendrobenzene fractionated oral, intravenous furosemide or uric acid and other powerful diuretics have rapid sodium, diuretic effect. For children with significant edema can give low molecular dextran.

 

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