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Pregnancy nephrotic syndrome requires timely termination of pregnancy

I had a good health before pregnancy, and began to have headache, dizziness, and lower extremity edema after 28 weeks of pregnancy. By 32 weeks, there was also a obvious swelling of the hips. Go to the hospital for examination and have been...

Pregnancy nephrotic syndrome requires timely termination of pregnancy

Aug 26, 2017 by Kidney Disease Expert

I had a good health before pregnancy, and began to have headache, dizziness, and lower extremity edema after 28 weeks of pregnancy. By 32 weeks, there was also a obvious swelling of the hips. Go to the hospital for examination and have been diagnosed with nephrotic syndrome. I wonder if this situation has any adverse effect on me and the fetus in the abdomen. Is it necessary to terminate the pregnancy in advance?

Gestational nephrotic syndrome is rare, the prevalence rate was only 0.02%-0.31%. The clinical feature is the emergence is"three highs and one low", namely a large number of proteinuria, high edema, hyperlipidemia and hypoproteinemia. In addition, because nephrotic syndrome in pregnancy is mostly developed on the basis of pregnancy induced hypertension, it is often associated with hypertension.
Nephrotic syndrome in pregnancy is more harmful to mother and fetus, and the adverse effect on mother is mainly caused by edema of tissue, resulting in uterine atony, which can lead to prolonged labor, increased postpartum hemorrhage and placental abruption. Adverse effects on the fetus is mainly due to the large number of liquid into the interstitial space, reduced blood volume, increase fetal distress and the incidence of growth retardation, easy to cause the risk of low birth weight, premature birth and stillbirth. In addition, clinical observation shows that the treatment effect of nephrotic syndrome in pregnancy is not ideal, and it is difficult to effectively improve the prognosis of the fetus.
So, once diagnosed as nephrotic syndrome during pregnancy, be sure to be in the basis of "three high and one low" and the treatment of hypertension, to the fetus reaches a certain maturity after considering the early termination of pregnancy. Generally, gestational weeks more than 34 weeks after the fetus has been basically mature, the best selection of appropriate ways to reduce the time of termination of pregnancy, fetal mortality, improve the pregnancy rate of control nephrotic syndrome, in order to ensure the life safety of mother and infant.

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