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Why does nephrotic syndrome cause thrombosis?

Why does nephrotic syndrome cause thrombosis ? Nephrotic syndrome, multiple mechanisms are involved in the process of the formation of thrombus, which is the most important function of platelet hyperfunction, abnormal blood coagulation syst...

Why does nephrotic syndrome cause thrombosis?

Sep 13, 2017 by Kidney Disease Expert

Why does nephrotic syndrome cause thrombosis? Nephrotic syndrome, multiple mechanisms are involved in the process of the formation of thrombus, which is the most important function of platelet hyperfunction, abnormal blood coagulation system, and the lack of endogenous anticoagulant and fibrinolytic system function.
Why does nephrotic syndrome cause thrombosis? The large amount of proteinuria produced by patients with nephrotic syndrome leads to a reduction in coagulation factors IX, XI, XII and prothrombin and antithrombin. The loss of these factors exceeds the amount of synthesis of the body and is mediated by coagulation factors The effect leads to an increase in coagulation factor II, VII, X. Studies have shown that protein C is a protein that relies on the anticoagulation of vitamin k, which inhibits the activity of coagulation factors V and VIII. Protein S is a cofactor of protein C activation, and these substances also contribute to thrombosis.
Why does nephrotic syndrome cause thrombosis? As an important factor in thrombosis, impaired fibrinolysis system is also common in patients with nephrotic syndrome. This is associated with a decrease in the concentration of plasminogen and plasminogen activator inhibitor -l associated with massive loss of urinary proteins. In addition, since albumin is a cofactor for plasminogen, fibrin and tissue plasminogen activator, the decrease in its concentration alone can attenuate fibrinolysis activity.

 Why does nephrotic syndrome cause thrombosis
Why does nephrotic syndrome cause thrombosis?

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