Why does nephrotic syndrome cause thrombosis? The large amount of proteinuria produced by patients with nephrotic syndrome leads to a reduction in coagulation factors IX, XI, XII and prothrombin and antithrombin. The loss of these factors exceeds the amount of synthesis of the body and is mediated by coagulation factors The effect leads to an increase in coagulation factor II, VII, X. Studies have shown that protein C is a protein that relies on the anticoagulation of vitamin k, which inhibits the activity of coagulation factors V and VIII. Protein S is a cofactor of protein C activation, and these substances also contribute to thrombosis.
Why does nephrotic syndrome cause thrombosis? As an important factor in thrombosis, impaired fibrinolysis system is also common in patients with nephrotic syndrome. This is associated with a decrease in the concentration of plasminogen and plasminogen activator inhibitor -l associated with massive loss of urinary proteins. In addition, since albumin is a cofactor for plasminogen, fibrin and tissue plasminogen activator, the decrease in its concentration alone can attenuate fibrinolysis activity.
Why does nephrotic syndrome cause thrombosis?