How to determine nephrotic syndrome? What are the nephrotic syndrome criteria?
With the increasing incidence of nephrotic syndrome, many people are suffering from the threat of nephrotic syndrome, then how do we determine whether we suffering from nephrotic syndrome or not? What are the nephrotic syndrome criteria? Here, Tongshantang experts to tell you the nephrotic syndrome criteria.
Nephrotic syndrome criteria are: (1) urinary protein more than 3.5g / d; (2) plasma albumin less than 30g / L; (3) edema; (4) elevated blood lipids. That (1) (2) is necessary for the criteria.
(1) a large number of proteinuria, in normal physiological conditions, glomerular filtration membrane with molecular barrier and charge barrier effect, with these barriers, especially when the charge barrier is impaired, glomerular filtration membrane on plasma protein mostly albumin-based) increased permeability, resulting in increased protein content in the original urine, when far more than the proximal tubule back to the amount of absorption, the formation of a large number of proteinuria. On this basis, where the increase in glomerular pressure and lead to high perfusion, high filtration factors (such as high blood pressure, high protein diet or a large number of infusion of plasma protein) can increase urinary protein excretion.
(2) edema, nephrotic syndrome, hypoalbuminemia, plasma colloid osmotic pressure decreased, so that water from the blood vessels into the tissue gap, is the basic cause of nephrotic syndrome edema. Recent studies have shown that about 50% of patients with normal or increased blood volume, plasma renin levels normal or decreased, suggesting that some of the original in the kidney of sodium, water retention factors in nephrotic syndrome edema mechanism play a certain role.
(3) changes in plasma proteins, a large number of albumin is lost from the urine, promoting albumin in the compensatory synthesis of the liver and an increase in renal tubular breakdown. Hypoalbuminemia occurs when the increase in albumin synthesis is insufficient to overcome loss and breakdown. In addition, patients with nephrotic syndrome due to gastrointestinal mucosal edema caused by eating loss, inadequate protein intake, poor absorption or loss, but also increase the cause of hypoalbuminemia.
(4) hyperlipidemia, high cholesterol and / or hypertriglyceridemia, serum LDL \, VLDL and lipoprotein (a) concentration increased, often associated with hypoalbuminemia. Its mechanism and liver synthesis of lipoprotein increased and decreased decomposition of lipoprotein, the current that the latter may be more important reasons for hyperlipidemia.
The above is what are the nephrotic syndrome criteria. According to the above description, the patient can determine whether he is suffering from nephrotic syndrome or not, if you have any more questions, please consult our online doctor or leave us a message.