Diabetic nephropathy is the serious microvascular complications, it is also the main reasons of the death of patients with diabetes. Patients with diabetes once appear renal damage and persistent proteinuria, the renal function reduce persistently, it can become renal failure in the end, there are no effective measures to stop the change and deterioration.
The clinical performances of diabetic nephropathy
1、Proteinuria: The early period of diabetic nephropathy have no clinical proteinuria, The radioimmuno-assay can check out microalbuminuria. The only performance of early clinical diabetic nephropathy is proteinuria, the proteinuria gradually from intermittent develop into sustainable stage.
2、Edema: The clinical diabetic nephropathy have no edema in the early stage, fewer patients have light edema before decreasing plasma protein. Patients have a lot of proteinuria and low plasma protein, the edema is aggravating, the disease has developed into the late stage.
3、High blood pressure: The morbidity of high blood pressure is not increasing among people without kidney disease in the type 1 diabetes. The type 2 patients with diabetes can accompany with high blood pressure, the rate of proteinuria is higher than the rate of high blood pressure,patients with nephrotic syndrome accompany with high blood pressure, the high blood pressure is mostly moderate, fewer patients have severe high blood pressure.
4、Renal failure: The fast and slow development of diabetic nephropathy have prodigious differences. Some patients with light proteinuria can last for many years, they have normal renal function. Some patients have less urine protein, it can develop quickly into nephrotic syndrome,renal function gradually deteriorate, it can develop into uremia.
(5)Anemia: Patients with obvious azotemia can have light anemia.
(6)Other organs complications: Heart failure、 myocardial infarction、 nervous lesion、retinopathy.