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Several stages of the development of kidney disease

A few days ago a patient asked me creatinine 390moI/L whether serious, after asked the other i told him that currently is in the loss of renal function, aggressive treatment of a great hope can achieve clinical cure. Then he asked, what is...

Several stages of the development of kidney disease

Jan 07, 2017 by Kidney Disease Expert

A few days ago a patient asked me creatinine 390μmoI/L whether serious, after asked the other i told him that currently is in the loss of renal function, aggressive treatment of a great hope can achieve clinical cure. Then he asked, "what is decompensation?

So today we talk about the stages of kidney disease, to see what stage you are in the end. Most of the patients are familiar with creatinine, so we use it as a reference standard:

Renal inflammation At this stage kidney function has not been damaged, only some urine protein and occult blood, edema, hypertension and other clinical indications. In addition edema and hypertension will make patients show obvious discomfort, urine protein and occult blood are "quiet". This stage is the most easy to cure, but many patients because the pain does not itch, missed the opportunity to treat, so regular physical examination is very important.

Compensatory stage of renal function. Compensatory stage of renal function renal function refers to the slight impairment of renal function, rely on the kidney's own compensatory function to meet the daily needs of the body. At this stage, the blood creatinine is basically between 133~177μmoI/L, about half of the renal units can work, so patients not feel anything, often delayed treatment. If we get timely and regular treatment, renal function can achieve clinical cure.

Decompensated stage of renal Decompensated stage of renal refers to the renal function is more serious, the kidney's own compensation function has been unable to meet the daily needs of the body. At this stage, the level of serum creatinine is between 178~442μmoI/L, and the renal damage has been more than 2/3 or more. At this point, the patient has begun to feel weak, but the symptoms are still not obvious. If get timely, regular treatment, there are still half the chance to achieve clinical cure.

Renal failure stage When the blood creatinine more than 443μmoI/L, it has entered the stage of renal failure, also known as chronic renal failure. At this point, the compensatory function of the kidney has been unable to make up  necrosis of renal units, the decline in renal function has entered an irreversible phase, there are a large number of kidney cells are killed. At this stage, the patient began to feel obvious symptoms, such as anemia, dizziness, fatigue, nausea, etc.. At the same time, some hospitals have even begun to recommend hemodialysis patients. The focus has been to slow the rate of decline in renal function, prevent kidney cells from continuing to become necrotic, and protect the residual renal function. 

Uremia stage Uremia are not unfamiliar, here we need to explain is: uremia is a stage, not an independent pathological type. Here again stressed: creatinine more than 707μmoI/L is not necessarily uremia period! The development of chronic renal failure to uremia period of about 15 years, at this time more than 90% of the renal unit has been necrosis, the volume of the kidney atrophy to less than 6cm, and there is no urine. At this stage, the patient's feelings will be very strong, dizziness, nausea, vomiting, heart failure, fatigue and other symptoms occur frequently. Due to excessive accumulation of toxins in the blood, other organs have begun to be violated. At this stage, the significance of the treatment has become as far as possible to maintain the normal life and reduce the pain of patients.

 

Author:An Lin

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