Question: Hello, I have something to ask about. I have a relative who has got interstitial nephritis. Creatinine is difficult to drop. Could you tell me what's the way, please?! The highest creatinine in 660, the patient was 64 years old.
Answer: Hello! I know about the patient. Creatinine is a product of muscle metabolism in our body, producing 1mg creatinine per 20g of muscle metabolism. Creatinine is mainly excreted by glomerular filtration. The patient's high creatinine is because his condition is not well controlled, resulting in continuous damage to the glomerulus, resulting in difficulty in excretion of creatinine.
Creatinine 660umol/l has been the period of renal failure, if you do not pay attention to the treatment of time, it will gradually toward the direction of uremia. The reason for this is because the interstitial nephritis can not carry out treatment from the root cause, there is no clear relationship between "disease" and "syndrome". Just routine symptomatic relief. Correct water, electrolyte, acid-base balance disorders, lower blood pressure, correct anemia and so on. This is a misunderstanding to the treatment, only pays attention to the relief of symptoms, and the disease was not targeted guidance. That is, there is no repair and reversal of the impairment of renal tubular epithelial cells and renal interstitial fibroblasts. Thus leading to repeated clinical indicators.
To cure kidney disease should not only pay attention to control the clinical indicators, it is more important for the renal pathological damage of renal tubular epithelial cells and interstitial fibroblasts function can effectively repair and reverse. Only in this way can the illness be brought under fundamental control. Achieve a very low recurrence rate of the treatment effect. The causes of renal interstitial nephritis are microbial infection, some physical and chemical factors, some metabolic diseases and immunological diseases.
Reabsorption, secretion and regulation are important functions of renal tubular epithelial cells, and are also important reasons why the kidney can regulate and influence the homeostasis of water and electrolyte and acid-base balance. Renal tubular epithelial cells undergo a phenotypic change, once damaged, itself is activated, the release of a series of inflammatory mediators and cytokines, into the renal interstitial infiltration of inflammatory reaction leads to renal interstitial inflammatory cells, lymphocytes, attract monocytes.
The damaged renal tubular epithelial cells also release a series of cytokines and growth factors, activate renal interstitial fibroblasts and promote proliferation. Activated fibroblasts undergo phenotypic transformation and become muscle fibroblasts. They synthesize collagen cells which are not degraded and promote the fibrosis and hardening of the interstitium. Therefore, we call it epithelial cell disease of the renal tubule, and use the integrated treatment of traditional Chinese and Western medicine. We call this method: "micro Chinese medicine" to block the infiltration of renal fibrosis. Through the long-term clinical observation, we can be sure that as long as the pathological damage has been effectively repaired and reversed, the clinical symptoms will naturally improve, not repeated. Greatly reduce the recurrence rate.