The increase of serum creatinine and urea nitrogen in renal function is not necessarily the renal insufficiency, which is affected by many factors.
Muscle tissue and metabolic status are the main extra-renal factors that affect serum creatinine. Muscular metabolism is reduced in patients with atrophic diseases. Increased protein synthesis, reduced creatinine, and serum creatinine may be slightly lower in pregnant women.
Fever and other catabolism can be enhanced, causing elevated serum creatinine;
High-protein diet can cause transient increase in serum creatinine. The amount of dietary protein, gastrointestinal bleeding, high catabolism, prerenal factors, cardiac insufficiency, etc., are the major extrarenal factors that affect blood urea nitrogen levels.
Under normal circumstances, tubular reabsorption of urea nitrogen about 30% -40%, and excretion of a small amount of urea nitrogen, when dehydration, insufficiency of blood volume and heart failure, renal blood flow was reduced, renal tubular reabsorption function was increased, urea nitrogen reabsorption increased, blood urea nitrogen concentration increased, and renal blood pressure was increased.
High protein diet, digestive tract bleeding, high catabolism, such as fever, increased the formation of urea nitrogen in the body and increased blood urea nitrogen. Therefore, the increase of blood urea nitrogen and blood creatinine does not necessarily indicate that the glomerular function is impaired and should be combined with the clinic.
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