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The causes and treatments of polycystic kidney disease

Causes Polycystic kidney disease (PKD) is a typical hereditary kidney disease. If one of the parents has PKD, the probability of child to catch such disease is 50 %( the incidence for boys and girls are equal). PKD is autosomal dominant tra...

The causes and treatments of polycystic kidney disease

Dec 03, 2013 by Kidney Disease Expert

Causes

Polycystic kidney disease (PKD) is a typical hereditary kidney disease. If one of the parents has PKD, the probability of child to catch such disease is 50 %( the incidence for boys and girls are equal). PKD is autosomal dominant trait hereditary disease. The condition of PKD progress slowly. In most cases, people will not be found to have PKD until their adulthood. Some of the patients may also have kidney stones and polycystic liver.

The cause of the production of countless cysts is a result of the abnormal epithelial cells in the kidney tubules which could transform to epithelial cells of the cyst wall. Once the transformation work is finished, the new epithelial cells gain the ability to produce fluid in a continuous way. When the amount of fluid increases and there is no way to expel them, the fluid will deposit in the cyst and the size of the cyst will keep increasing, so will the pressure in the cyst.

At this stage, some of the patients may have symptoms such as swelling and pain in lower back. With the increasing size of the cyst, the enlarged cyst may even affect the normal structure of the kidney, the function of glomerulus to concentrate, absorb and adjust fluid will gradually loss. Thus the routine urine test and kidney function test as well as the blood pressure will show abnormal results.

Treatments

As we can not change the gene of the human beings, the clinical treatment should focus on the cysts. The treatment combines both Chinese and western therapy. The western therapy is to alleviate the clinical symptoms and the Chinese therapy is to fundamentally resist the growth of the cysts. The Chinese therapy controls the growth of the cysts through inactivating the epithelial cells (it is the epithelial cells in the kidney that producing fluid continuously), so that the epithelial cells can no longer secrete fluid.

Once the epithelial cells stop secreting fluid, the cysts will remain their size, after that, the application of Chinese medicine will increase the permeability of the cysts surface so as to let the fluid be absorbed and be expelled out of body through urine. This is the right treatment for PKD which could not only alleviate the symptoms but also prevent the condition from recurrence.

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