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Can grapefruit cause kidney failure?

Many people can not resist the temptation of grapefruit sweet, but for patients with kidney disease, still have to pay attention to one thing, take the following two kinds of kidney medicine drugs, or do not eat grapefruit or grapefruit jui...

Can grapefruit cause kidney failure?

Nov 08, 2017 by Kidney Disease Expert

Many people can not resist the temptation of grapefruit sweet, but for patients with kidney disease, still have to pay attention to one thing, take the following two kinds of kidney medicine drugs, or do not eat grapefruit or grapefruit juice drink.

Can grapefruit cause kidney failure?

The study found that grapefruit contain compounds called furanocoumarins active compounds, this compound can inhibit human cytochrome P450 (CYP3A4) synthesis, and tacrolimus and cyclosporine is needed to complete the normal cytochrome metabolism.

Consumption of grapefruit increases the systemic exposure of cyclosporine and tacrolimus, which increases the toxicity of these two drugs and aggravates kidney injury.

In addition to these two common drugs, statins, lipid-lowering drugs, and calcium channel blockers antihypertensive drugs, etc., will be affected by grapefruit.

But there is no serious impact of the above two drugs, that is to say, you can eat at this time, but not excessive! No more than half!

Common statins:

Simvastatin, lovastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin and so on.

Antihypertensive drugs of calcium channel blockers:

A class is two dihydropyridine, mainly nifedipine, nicardipine, nitrendipine, felodipine and amlodipine, lassy equality. The other is thiadipone, including diltiazem sustained-release tablets, diltiazem, Cardizem, Steele etc..

 

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